In addition to the DPRA, h-CLAT and LuSens test methods, we now offer the U-SENS™ assay for assessing skin sensitisation potential of chemicals and other products.
The assay comprises investigation of cytotoxicity and a possible increase in expression of the CD 86 cell surface marker after exposure to a potential sensitiser as measured by flow cytometry. The U-SENS™ assay is together with the h-CLAT test method described in the OECD TG 442E, but in contrast to the h-CLAT method, the U-SENS™ assay doesn’t take log Pow of a test substance into consideration for any classification for skin sensitisation.
The U-SENS™ assay is suitable for testing all substances that are soluble in DMSO or culture media, including pre-haptens, pro-haptens, cosmetic ingredients or weakly fluorescent substances.
Our experts are happy to support you in developing a proper testing strategy for assessing the skin sensitisation potential of your test substance.