ICCR now offers the in vitro U-SENS™ assay (OECD 442E, Annex II)

In addition to the DPRA, h-CLAT and LuSens test methods, we now offer the U-SENS™ assay for assessing skin sensitisation potential of chemicals and other products.

The assay comprises investigation of cytotoxicity and a possible increase in expression of the CD 86 cell surface marker after exposure to a potential sensitiser as measured by flow cytometry. The U-SENS™ assay is together with the h-CLAT test method described in the OECD TG 442E, but in contrast to the h-CLAT method, the U-SENS™ assay doesn’t take log Pow of a test substance into consideration for any classification for skin sensitisation.

The U-SENS™ assay is suitable for testing all substances that are soluble in DMSO or culture media, including pre-haptens, pro-haptens, cosmetic ingredients or weakly fluorescent substances.

Our experts are happy to support you in developing a proper testing strategy for assessing the skin sensitisation potential of your test substance.

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