Alternative methods for safer cosmetics

In our modern world, the trend towards individualisation and self-expression with cosmetic products is ever more important.

A producer of cosmetics is responsible for the safety of their products towards the consumer and we support you to guarantee that safety through a multitude of animal-free test methods. Our expertise ranges from the use of primary cells to permanent cell lines and 3D-tissue models and we’re happy to meet your special needs.

Our test methods

In vitro Skin Irritation: Reconstructed Human Epidermis Test method OECD 439
EpiOral/EpiGingival Test ISO 10993/EN ISO 7405
EpiVaginal Test ISO 10993-23
In vitro Skin Corrosion: Reconstructed Human Epidermis Test method) OECD 431
In vitro Skin Corrosion: Corrositex – In vitro Membrane Barrier Test method OECD 435
Eye Irritation: Reconstructed human Cornea-like Epithelium Test method OECD 492
Bovine Cornea Opacity and Permeability Test (BCOP) OECD 437
Short Time Exposure in vitro Test Method for Identifying Eye Damage (STE) OECD 491
Hen’s Egg Test – Chorioallantoic Membrane (HET-CAM) INVITTOX Protocol No. 47
Direct Peptide Reactivity Assay (DPRA) OECD 442C (Appendix I)
The ARE-Nrf2 luciferase LuSens test method (LuSens) OECD 442D (Appendix IB)
Human Cell Line Activation test (h-CLAT) OECD 442E (Annex I)
XTT test ISO 10993-5 /  ISO 7405
MTT test ISO 10993-5 /  ISO 7405
Neutral red uptake (NRU) ISO 10993-5 /  ISO 7405
Agar overlay assay ISO 10993-5 /  ISO 7405
Elution Test USP 87
In vitro 3T3 NRU Phototoxicity Test OECD 432
In vitro gene mutation study in bacteria: Ames Test OECD 471  / OPPTS / ICH
In vitro gene mutation study in mammalian cells: Mouse Lymphoma Assay (MLTK Assay) OECD 490 / OPPTS / ICH
In vitro gene mutation study in mammalian cells: HPRT test OECD 476 / OPPTS / ICH
Micronucleus Assay in vitro (Human Lymphocytes or V79 cells) OECD 487 / OPPTS / ICH
Chromosomal aberration Assay in vitro (Human Lymphocytes or V79 cells) OECD 473 / OPPTS / ICH
Hen’s Egg Test – Induction of Micronuclei (HET-MN)
Cell Transformation Assay in Bhas Cells OECD 231 (draft)
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